Levodopa-induced dyskinesias in mitochondrial membrane protein–associated neurodegeneration
نویسندگان
چکیده
منابع مشابه
Levodopa-induced dyskinesias in tyrosine hydroxylase deficiency.
The objective of this study was to characterize levodopa (l-dopa)-induced dyskinesias in patients with tyrosine hydroxylase deficiency. Clinical observation was carried out on 6 patients who were diagnosed with tyrosine hydroxylase deficiency and were treated with escalating doses of l-dopa. All 6 patients showed l-dopa-induced dyskinesias of variable intensity early in the course of treatment ...
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Experimental models of Parkinson's disease have demonstrated abnormal synaptic plasticity in the corticostriatal system, possibly related to the development of levodopa-induced dyskinesias (LID). We tested the hypothesis that LID in Parkinson's disease is associated with aberrant plasticity in the human motor cortex (M1). We employed the paired associative stimulation (PAS) protocol, an experim...
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Metoclopramide is an antiemetic drug which occasionally produced acute dystonic reactions. Although known to interfere with central dopamine mechanisms, it is frequently used in Parkinson's disease to prevent levodopa-induced nausea and vomiting. In this study metoclopramide did not increase Parkinsonism or reduce levodopa-induced involuntary movements in patients with Parkinson's disease. Pimo...
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1 IBFM, National Research Council, Catanzaro, Italy 2 Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia IRCCS, Rome, Italy 3 Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson’s Disease, Division of Neurology, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada 4 Dipartimento di Medicina Clinica e Sper...
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ژورنال
عنوان ژورنال: Neurology: Clinical Practice
سال: 2018
ISSN: 2163-0402,2163-0933
DOI: 10.1212/cpj.0000000000000577